Characteristics of the intestinal microbiota in patients with colorectal cancer

Abstract

AIM: to study the intestinal microbiota and identify its characteristic features in patients with colorectal cancer.PATIENTS AND METHODS: in this study, the composition of the intestinal microbiota in patients with colorectal cancer was analyzed, while the comparison group consisted of patients with non-inflammatory bowel diseases.RESULTS: previous studies have shown the possible role of enterococci and some types of clostridia in stimulating oncogenic processes and, on the contrary, the vital role of lactobacilli and bifidobacteria in intestinal homeostasis maintaining. The aim of this study was to compare the gut microbiota composition in colorectal cancer patients and non-inflammatory bowel diseases patients gut microbita. The proportion of enterococci was increased in patients with colorectal cancer (12.7% in the study group and 7.6% in the control group) on the contrary the proportion of bifidobacteria and obligate anaerobes was decreased (1.5% in the study group and 4% in the control groups) and (3.3 % of the study group and 9.7% in the control group) respectively. Decrease of the microbiota biodiversity was observed for the patients with colorectal cancer that was calculated by the Shannon diversity Index (4.46 in the study group and 4.8 in the control group), also two-fold increase of Pseudomonas aeruginosa share (2.2% in the study group and 1.1% in the control group) was found for this cohort, Clostridium septicum was isolated only from patients with colorectal cancer.CONCLUSION: this study results suggest the diagnostic significance of the species diversity of the intestinal microbiota.