Comparison of REMS, NEWS, qSOFA scales and SIRS criteria in sepsis prediction for patients with confirmed SARS-CoV-2 infection: retrospective observational study

Annals of pulmonary and critical care medicine Pub Date : 2021-01-01 DOI:10.21320/1818-474X-2021-1-48-56

K. Zybin, A. A. Noskov, T. Musaeva, M. Kuznetsova, S. Goncharenko, O. Vysotsky, P.I. Danilyuk, E. S. Petrushenko, M.I. Veselenko, A. Potapova, S. V. Sinkov, V. M. Durleshter

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Abstract

Introduction. Novel coronavirus disease is often accompanied by sepsis. This leads us to search of sepsis prediction tools. Objectives. Comparison of REMS, NEWS, qSOFA scales and SIRS criteria in sepsis prediction for patients with confirmed SARS-CoV-2 infection. Materials and methods. 167 medical cards retrospective analysis of patients with confirmed SARS-CoV-2 infection on admission to ICU. Results. In sepsis prediction only NEWS (0,819 [95% CI 0.738–0,884]) showed resolution high enough to serve as supplemental clinical information. REMS (0.798 [95% CI 0.715–0.866]), qSOFA (0.716 [95% CI 0.626–0.795]) and SIRS criteria (0.710 [95% CI 0.620–0.790]) showed insufficient resolution in sepsis prediction for patients with SARS-CoV-2. NEWS in pairwise comparison showed significantly better resolution than qSOFA (p = 0.002) and SIRS criteria (p = 0.013). All scales showed good calibration. Conclusions. Only NEWS scale showed good resolution and calibration and can be used as supplemental clinical information in sepsis prediction for patients with SARSCoV-2 infection.

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REMS、NEWS、qSOFA量表和SIRS标准在预测确诊SARS-CoV-2感染患者败血症中的比较:回顾性观察研究

介绍。新型冠状病毒病常伴有败血症。这导致我们寻找脓毒症预测工具。目标。REMS、NEWS、qSOFA量表和SIRS标准对SARS-CoV-2确诊患者脓毒症预测的比较材料和方法。重症监护病房确诊SARS-CoV-2感染患者167张医疗卡回顾性分析结果。在脓毒症预测中，只有NEWS (0.819 [95% CI 0.738 - 0.884])的分辨率足够高，可作为补充临床信息。REMS (0.798 [95% CI 0.715-0.866])、qSOFA (0.716 [95% CI 0.626-0.795])和SIRS标准(0.710 [95% CI 0.620-0.790])在预测SARS-CoV-2患者败血症方面存在不足。NEWS两两比较的分辨率明显优于qSOFA (p = 0.002)和SIRS标准(p = 0.013)。所有量表均显示出良好的校准。结论。只有NEWS量表具有较好的分辨率和校准性，可作为SARSCoV-2感染患者脓毒症预测的补充临床信息。

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Annals of pulmonary and critical care medicine

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