Platelet Rich Fibrin (PRF) : un nouveau biomatériau de cicatrisation

Implantodontie Pub Date : 2004-10-01 DOI:10.1016/j.implan.2004.07.002

J. Choukroun , A. Simonpieri , M.-O. Girard , F. Fioretti , S. Dohan , D. Dohan

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引用次数: 9

Abstract

The PRF (Platelet Rich Fibrin) belongs to a new generation of platelet concentrates, with simplified modes of production and without biochemical handling of blood (heparin, EDTA, bovine thrombin, Calcium chloride…). In this fourth article, we sought to correlate the previously evaluated biology of the PRF with first established clinical results, in order to determine the potential fields of application of this biomaterial. Our reasoning is structured around four fundamental events of the cicatrisation: angiogenesis, immune control, circulating stem cells trapping and wound covering epithelialisation. Indeed, all the known clinical applications of the PRF highlight an accelerated tissue cicatrisation because of the development of an effective neovascularization, an accelerated wound closing with fast cicatricial tissue remodelling and the quasi-total absence of infectious events. This first work thus makes it possible to plan many future applications for the PRF, as well in plastic surgery as in bone surgery, provided that its real effects are evaluated in an impartial and rigorous way.

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富血小板纤维蛋白(PRF):一种新型愈合生物材料

富血小板纤维蛋白(PRF)是新一代血小板浓缩物，生产方式简化，无需血液生化处理(肝素、EDTA、牛凝血酶、氯化钙等)。在这第四篇文章中，我们试图将先前评估的PRF生物学与首次建立的临床结果联系起来，以确定这种生物材料的潜在应用领域。我们的推理是围绕四个基本事件:血管生成，免疫控制，循环干细胞捕获和伤口覆盖上皮化。事实上，所有已知的PRF临床应用都强调了由于有效的新生血管的发展、快速瘢痕组织重塑和几乎完全没有感染事件的加速伤口愈合。因此，这第一项工作使得计划PRF在整形外科和骨外科中的许多未来应用成为可能，前提是以公正和严格的方式评估其实际效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Implantodontie

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