A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS

Toxic substance mechanisms Pub Date : 1997-07-01 DOI:10.1080/107691897229586

M. Garba, A. Mustapha, M. Bakare, I. Aguye

引用次数: 2

Abstract

Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.

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在健康志愿者中，短暂的交流减少了西咪替丁后扑热息痛的吸收

西咪替丁未被证明会影响扑热息痛的药代动力学。然而，当对方案进行修改，使扑热息痛在西咪替丁后1小时服用时，对其吸收有显著影响。C和K(吸收常数)显著降低(对照组和处理组最大差异p < 0.001)。延迟时间显著增加(p < 0.001)。这表明扑热息痛的治疗效果可能会受到影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxic substance mechanisms

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