M. Abbasi, Seong-Hui Eo, A. Rehman, S. Z. Siddiqui, Yohan Han, Seon-Mi Yu, Song-Ja Kim, Mubashir Hassan, H. Raza, S. A. Shah, S. Seo, Bandar Puncak Alam Selangor Darul Ehsan Malaysia. Puncak Alam Campus
{"title":"Anti-proliferative and migratory inhibition study of b16f10 in mouse melanoma cells induced by synthetic indole-oxadiazole bearing butanamides","authors":"M. Abbasi, Seong-Hui Eo, A. Rehman, S. Z. Siddiqui, Yohan Han, Seon-Mi Yu, Song-Ja Kim, Mubashir Hassan, H. Raza, S. A. Shah, S. Seo, Bandar Puncak Alam Selangor Darul Ehsan Malaysia. Puncak Alam Campus","doi":"10.30538/PSRP-OJC2019.0010","DOIUrl":null,"url":null,"abstract":"Matrix metalloproteinases-2 and -9 (MMP-2/-9) are key tissue remodeling enzymes that have multiple overlapping activities critical for wound healing and tumor progression. In search of new anti-tumor agents, indole-oxadiazole containing butanamides (1-5) were evaluated with B16F10 mouse melanoma cells in this study. The results showed that compounds 1, 2 and 3 inhibited the cell proliferation in a considerable manner at concentrations ranging from 0-44 ?M. The possible migration inhibitory effects of these melanoma cells were further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells and it was inferred that compounds 1, 2 and 3 affected the expression and activity of these enzymes in a dose dependent manner while compound 1 can be regarded as promising anti-tumor agent.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open journal of physical chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30538/PSRP-OJC2019.0010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Matrix metalloproteinases-2 and -9 (MMP-2/-9) are key tissue remodeling enzymes that have multiple overlapping activities critical for wound healing and tumor progression. In search of new anti-tumor agents, indole-oxadiazole containing butanamides (1-5) were evaluated with B16F10 mouse melanoma cells in this study. The results showed that compounds 1, 2 and 3 inhibited the cell proliferation in a considerable manner at concentrations ranging from 0-44 ?M. The possible migration inhibitory effects of these melanoma cells were further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells and it was inferred that compounds 1, 2 and 3 affected the expression and activity of these enzymes in a dose dependent manner while compound 1 can be regarded as promising anti-tumor agent.