THE EFFECTS OF INTERACTIONS BETWEEN TESTOSTERONE AND GHRELIN ON MEAN PLASMA THYROID HORMONES CONCENTRATION IN MALE RATS

Progress in Biological Sciences Pub Date : 2016-06-01 DOI:10.22059/PBS.2016.59007

sina - taghvimi, H. Khazali, Farzaneh Haghnazari

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Abstract

Ghrelin is an orexigenic peptide synthesized mainly by stomach and hypothalamus. Ghrelin decreases secretion of thyroid hormones. Testosterone is an esteroidogenic hormone that exerts stimulatory effects on Hypothalamus-Pituitary-Thyroid (HPT) axis activity. The aim of the present study was to investigate the effect of interactions between the central injection of ghrelin and testosterone on mean plasma thyroid hormones concentration. Twenty male Wistar rats (200-250 g) were randomly divided into four groups. The groups received saline, 5 nmol ghrelin, 1 μg testosterone and simultaneous injection of 5 nmol ghrelin and 1 μg testosterone in third cerebral ventricle in volumes of 3 μl. Blood samples were collected one day before injection and until 12 hours after that. Mean plasma thyroid hormones concentrations were determined by radio-immunoassay (RIA). The results indicated that testosterone significantly increased the mean plasma concentration of T3 and T4 hormones after injection compared to before injection, whereas ghrelin significantly decreased the mean plasma concentration of T3 and T4 compared to before injection. The results demonstrated that ghrelin significantly decreased the stimulatory effect of testosterone on mean plasma T3 and T4 concentrations.

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睾酮与胃饥饿素相互作用对雄性大鼠平均血浆甲状腺激素浓度的影响

胃饥饿素是一种主要由胃和下丘脑合成的促氧肽。胃饥饿素减少甲状腺激素的分泌。睾酮是一种甾体激素，对下丘脑-垂体-甲状腺(HPT)轴的活性有刺激作用。本研究的目的是探讨中心注射胃饥饿素和睾酮对平均血浆甲状腺激素浓度的影响。雄性Wistar大鼠20只(200 ~ 250 g)，随机分为4组。各组分别给予生理盐水、胃饥饿素5 nmol、睾酮1 μg，并在第三脑室同时注射胃饥饿素5 nmol、睾酮1 μl，注射量为3 μl。注射前1天及注射后12小时采集血样。用放射免疫分析法(RIA)测定血浆甲状腺激素平均浓度。结果显示，睾酮注射后较注射前显著升高T3、T4激素的平均血浆浓度，而胃饥饿素注射后较注射前显著降低T3、T4激素的平均血浆浓度。结果表明，胃饥饿素显著降低睾酮对血浆平均T3和T4浓度的刺激作用。

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Progress in Biological Sciences

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