Impact of COVID-19 on the signs of human ageing

A. Pisaruk, N. Koshel, Ludmila Pysaruk, V. Shatilo
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Abstract

Abstract. The symptoms of post-COVID-19 syndrome (PPCS) are nonspecific and similar to those signs of aging. Therefore, it was suggested that those who have recovered from COVID-19 have accelerating the aging of the body. The aim of this work was to assess the influence of COVID-19 on the frequency of signs of aging. To collect the data, there was used a developed questionnaire, which included 17 signs of aging. There were received the answers from 306 people at the age from 30 to 70 years old. Among them, 98 people have had COVID-19. The average age of the people in the post-COVID-19 and COVID-19-free groups was 51,3 ± 1,65 and 50,4 ± 1,17, respectively (p> 0,05). The frequency of 14 signs of aging was significantly (p <0,01) higher among post-COVID-19 people. Particularly significant differences between post-COVID-19 and COVID-19-free were in the group of people under the age of 50 years old. The data, received by us, allowed to develop a computational procedure for diagnosing of PPCS. The task of attributing of the surveyed people to the post-COVID-19 and COVID-19-free group in accordance with the presence of certain symptoms was solved with the help of the Bayesian method in Gubler's modification, multiple logistic regression and neural network analysis. The developed diagnostic procedures can be used for the identification of the people with a high probability of the developing of PPCS. Keywords: rate of aging, post-COVID-19 syndrome, questionnaire
COVID-19对人类衰老迹象的影响
摘要covid -19后综合征(PPCS)的症状是非特异性的,与衰老的迹象相似。因此,有分析认为,从新冠肺炎中恢复过来的人加速了身体的衰老。这项工作的目的是评估COVID-19对衰老迹象频率的影响。为了收集数据,研究人员使用了一份调查问卷,其中包括17种衰老迹象。调查收到了306名年龄在30岁至70岁之间的人的回答。其中98人感染新冠肺炎。感染后组和未感染组的平均年龄分别为51,3±1,65岁和50,4±1,17岁(p> 0.05)。新冠肺炎后患者出现14种衰老迹象的频率显著高于对照组(p < 0.01)。在50岁以下人群中,covid -19后和未感染covid -19之间的差异尤为显著。我们收到的数据,允许开发诊断PPCS的计算程序。通过Gubler修正中的贝叶斯方法、多元逻辑回归和神经网络分析,解决了根据某些症状将被调查者归属于新冠肺炎后和非新冠肺炎人群的任务。开发的诊断程序可用于鉴别患PPCS的高概率人群。关键词:老龄化率,后冠状病毒综合征,问卷调查
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