Association of Hs-CRP Levels in Patients with Acute Coronary Syndromes and it’s Correlation with Angiographic Severity of Coronary Artery Stenosis

A. Sharma
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引用次数: 1

Abstract

Significant advances have been made toward the development of biomarkers for prognostication of patients with atherosclerotic cardiovascular disease. One such marker is high-sensitivity C-reactive protein (hsCRP). It is a marker of inflammation mainly used to predict the risk of adverse cardiovascular (CV) events. Recent research also supports its role in atherogenesis. It is involved throughout the process of atheromatous plaque development. However, limited information is available about the relationship between levels of hs-CRP levels in patients presenting with acute coronary syndromes (ACS) and its association with outcomes. We conducted this study to assess the correlation between the levels of hs-CRP and the coronary angiographic findings in patients presenting with ACS and its correlation with outcomes. we carried an observational prospective study in patients presenting with ACS admitted to cardiology intensive coronary care unit in a tertiary care hospital. Patients underwent invasive coronary angiogram and serum Hs-CRP levels testing apart from other routine investigations. Correlation between severity of coronary stenosis, Hs-CRP levels and left ventricular ejection fraction (LVEF) at discharge was then assessed using statistical analysis. Positive correlation was found between Hs-CRP levels and severity of coronary stenosis. Negative correlation was found between Hs-CRP levels and LVEF at discharge. We found that hs-CRP levels correlate well with angiographic severity. It was also observed that higher the hs-CRP levels more the number of vessels involved with patients with the left main + triple vessel disease (TVD) and TVD having maximum scores.
急性冠脉综合征患者Hs-CRP水平的相关性及其与冠脉狭窄程度的相关性
在动脉粥样硬化性心血管疾病患者预后的生物标志物开发方面取得了重大进展。其中一个这样的标记是高灵敏度c反应蛋白(hsCRP)。它是一种炎症标志物,主要用于预测心血管不良事件的风险。最近的研究也支持它在动脉粥样硬化中的作用。它参与了动脉粥样硬化斑块形成的整个过程。然而,关于急性冠脉综合征(ACS)患者hs-CRP水平及其与预后的关系的信息有限。我们进行了这项研究,以评估hs-CRP水平与ACS患者冠状动脉造影结果之间的相关性及其与预后的相关性。我们进行了一项观察性前瞻性研究,研究对象是在一家三级保健医院心脏病科冠状动脉重症监护室就诊的ACS患者。除其他常规检查外,患者接受有创冠状动脉造影和血清Hs-CRP水平检测。然后采用统计学分析评估冠状动脉狭窄严重程度、Hs-CRP水平与出院时左室射血分数(LVEF)的相关性。Hs-CRP水平与冠状动脉狭窄严重程度呈正相关。出院时Hs-CRP水平与LVEF呈负相关。我们发现hs-CRP水平与血管造影严重程度密切相关。此外,hs-CRP水平越高,左主干+三支血管病变(TVD)和TVD评分最高的患者受累血管数量越多。
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