A Classification Method for RNA Splicing Regulatory Elements

Q4 Medicine
Meng Ma, Yang Wang, Ying Ru, Zefeng Wang
{"title":"A Classification Method for RNA Splicing Regulatory Elements","authors":"Meng Ma, Yang Wang, Ying Ru, Zefeng Wang","doi":"10.3969/J.ISSN.0258-8021.2012.01.008","DOIUrl":null,"url":null,"abstract":"The sequence classification methods have broad application in various bioinformatics areas such as the identification of regulatory elements of transcription and the prediction of protein structure.Here we presented a new classification method to analyze short sequences based on their sequential features,and used this method to study RNA splicing regulatory elements.This method extracted the sequential features from the known spicing regulatory elements,and developed a scoring system to evaluate how possible a given short sequence can regulate RNA splicing.This method was compared with some other methods through applying to a set of exonic splicing enhancer(ESE) and silencer(ESS) octamers.The average prediction accuracy of this sequential feature-based method for three kinds of computation validation experiments reached about 93% and the transparent predictive structure of the method helps to interpret the biological mechanism.This paper shows a new method for biology series' data analysis and presents a new way for the study of regulatory sequences that control gene expression.","PeriodicalId":35998,"journal":{"name":"中国生物医学工程学报","volume":"14 1","pages":"45-52"},"PeriodicalIF":0.0000,"publicationDate":"2012-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国生物医学工程学报","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3969/J.ISSN.0258-8021.2012.01.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

The sequence classification methods have broad application in various bioinformatics areas such as the identification of regulatory elements of transcription and the prediction of protein structure.Here we presented a new classification method to analyze short sequences based on their sequential features,and used this method to study RNA splicing regulatory elements.This method extracted the sequential features from the known spicing regulatory elements,and developed a scoring system to evaluate how possible a given short sequence can regulate RNA splicing.This method was compared with some other methods through applying to a set of exonic splicing enhancer(ESE) and silencer(ESS) octamers.The average prediction accuracy of this sequential feature-based method for three kinds of computation validation experiments reached about 93% and the transparent predictive structure of the method helps to interpret the biological mechanism.This paper shows a new method for biology series' data analysis and presents a new way for the study of regulatory sequences that control gene expression.
RNA剪接调控元件的分类方法
序列分类方法在转录调控元件的鉴定、蛋白质结构的预测等生物信息学领域有着广泛的应用。本文提出了一种基于序列特征分析短序列的新分类方法,并利用该方法对RNA剪接调控元件进行了研究。该方法从已知的香料调节元件中提取序列特征,并开发了一个评分系统来评估给定短序列对RNA剪接的调节可能性。将该方法应用于一组外显子剪接增强子(ESE)和沉默子(ESS)八聚体,并与其他方法进行了比较。基于序列特征的方法在三种计算验证实验中的平均预测准确率达到93%左右,该方法透明的预测结构有助于解释生物机制。本文提出了一种生物序列数据分析的新方法,为研究控制基因表达的调控序列提供了一条新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
中国生物医学工程学报
中国生物医学工程学报 Medicine-Medicine (miscellaneous)
CiteScore
0.40
自引率
0.00%
发文量
2798
期刊介绍: The mission of our journal: to be the bridge of the clinician, scientist and the industrial field, and to be the power of the development of biomedical engineering. The tenet of our journal: closely paying attention to and reporting the new theory, new means and new technology of biomedical engineering, tracking the newest applied achievement of biomedical engineering in clinic, serving vast clinicians, and promoting the developing of the subject of biomedical engineering. The feature of our journal: paying attention to the progress of science and technology, simultaneously, comprehensively weigh the relationship between the technology and one’s health in mind and body.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信