Effects of large dose of statins on renal function, vascular endothelial function and levels of inflammatory factor in patients with coronary heart disease complicated with renal insufficiency

Abstract

Objective To analyze the effects of large dose of rosuvastatin on renal function, vascular endothelial function and levels of inflammatory factor in patients with coronary heart disease complicated with renal insufficiency. Methods Sixty patients with coronary heart disease complicated with renal insufficiency admitted to the Second People’s Hospital from January 2015 to December 2018 were randomly divided into the control group and study group by random number table method, with 30 patients in each group. Patients in the control group were treated with conventional dose of rosuvastatin, and patients in the study group were treated with large dose of rosuvastatin. The renal function, vascular endothelial function, levels of inflammatory factor and incidence of adverse reactions were compared between the two groups. Results There was no significant difference in 24 h urinary protein or serum creatinine between the two groups before treatment (P>0.05); after treatment, the levels of 24 h urinary protein and serum creatinie decreased in both groups, and the study group had higher 24 h urinary protein level than the control group (P 0.05). After treatment, Hcy levels decreased, but NO and eNOS levels increased in both groups; compared to control group, and the Hcy levels in the study group were lower, while NO and eNOS levels were higher (P 0.05). The incidence of adverse reaction of the study group was 33.33% (10/30), higher than the 26.67% (8/30) of the control group, but there was no significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusions Large dose of rosuvastatin in the treatment of patients with coronary heart disease and renal insufficiency can significantly improve renal function and vascular endothelial function, and reduce inflammation levels, without increasing incidence of adverse reactions. Key words: Large dose; Statins; Coronary heart disease; Renal insufficiency; Renal function; Vascular endothelial function; Inflammatory factors