Estimating subject-specific hazard functions

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-24 DOI:10.1093/jrsssc/qlad030

Moumita Chatterjee, B. Ganguli, Sugata Sen Roy

引用次数: 0

Abstract

The central idea of this paper is to compare mean responses of several subjects in the presence of censoring and subject-specific variation. We develop a semiparametric mixed model for fitting subject-specific hazard curves to a set of censored failure times. A spline-based model and a mixed effects framework for smoothing are used. Efficient estimators of fixed parameters and predictors of the random components are derived and their asymptotic properties studied. This is a generalization of the method proposed by [Cai, T., Hyndman, R. J., & Wand, M. P. (2002). Mixed model-based hazard estimation. Journal of Computational and Graphical Statistics, 11(4), 784–798. https://doi.org/10.1198/106186002862] to incorporate additional subject-specific variation of the hazard function. The results are illustrated using two motivating examples.

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估计特定主题的危害函数

本文的中心思想是比较几个受试者在审查和受试者特定变化的情况下的平均反应。我们开发了一个半参数混合模型，用于拟合主题特定的危险曲线到一组截尾失效时间。使用基于样条的模型和混合效果框架进行平滑。导出了固定参数的有效估计量和随机分量的有效预测量，并研究了它们的渐近性质。这是对Cai, T.， Hyndman, R. J, and Wand, M. P.(2002)提出的方法的推广。基于混合模型的危害估计。计算与图形统计，11(4)，784-798。https://doi.org/10.1198/106186002862]以纳入额外的针对特定主题的危险函数变化。用两个实例说明了结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.