Polymorphism in Long Non-Coding RNA- HOXA Transcript at The Distal Tip Among Rheumatoid Arthritis Patients

Abstract

Limited studies have explored the correlation between lncRNA HOTTIP single nucleotide polymorphisms (SNPs) and RA. This study aimed to evaluate the genetic association of single nucleotide polymorphism rs3807598 (C:G) of HOTTIP among rheumatoid arthritis patients. Method: The study included 120 subjects from 2 groups: 60 RA patients and 60 healthy controls. Real-time PCR with TaqMan allelic discrimination assay was used to perform the genotyping. The odds ratios (ORs) models and 95% confidence interval (CIs) were used to test the associations. Results: The results indicated that lncRNA HOTTIP SNP rs3807598 (C:G) exhibited a statistically nonsignificant association with the risk of RA. Conclusion : Up-to-date, the role of HOTTIP SNPs in RA risk is still unknown, It is important to consider how epigenetic modifications including non-coding RNAs polymorphism and expression affect the RA risk and how well it responds to treatment. Further studies, with a larger sample size, could highlight more significant relations between SNPs of non-coding RNAs and RA.