Effect of Lipid Peroxidation Products on the Catabolic Fate of Nicotinamide in Rats
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Abstract
high-performance liquid chromatographic measurements of nicotinamide3' and its major catabolic metabolites such as MNA,4) 2-Py,5) and A^-methyM-pyridone-S-carboxamide (4-Py),6) and have been investigating the effects of nutrients on the metabolic fate of nicotinamide in rats. However, our results did not indicate any evident relationship between the urinary excretion of (2-Py+4Py)/MNAand niacin status. Under speciffed conditions, its excretion ratio reflected an adequacy of amino acid nutrition,7~12) and even when the amino acid nutrition was adequate, an excess administration of tryptophan,13)脂质过氧化产物对大鼠烟酰胺分解代谢的影响
高效液相色谱法测定了烟酰胺3′及其主要分解代谢产物如MNA,4) 2-Py,5)和A^-甲基-吡啶酮- s -羧酰胺(4- py)，6)，并研究了营养物质对烟酰胺代谢命运的影响。然而，我们的研究结果并没有显示尿中(2-Py+4Py)/ mna与烟酸状态之间有任何明显的关系。在特定的条件下，它的排泄率反映了氨基酸营养的充足性(7~12)，即使氨基酸营养充足，色氨酸的过量摄入(13)。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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