Estrogen and Progesterone Receptors in Endometrial Cancer: Where Are We Today?

Abstract

Immunohistochemistry of estrogen receptor (ER) and progesterone receptor (PR) is not routinely adopted by clinicians for the management of endometrial cancers. However, they may have significant importance in determining tumor behaviour and selection of an appropriate treatment protocol. An insight into the role of ER and PR in endometrial cancers is needed for optimizing outcome. The mechanism of action of these receptors in endometrial carcinoma needs to be clearly understood.