Lysophosphatidic Acid- A Target in Ovarian and Endometrial Cancer Therapy

Abstract

Lysophosphatidic acid (LPA), one of the simplest and most potent lysophospholipids exerting many physiological and pathological actions on various cell types, plays also an essential role in tumorigenesis and cancer metastasis. Overexpression of LPA and its receptors is a common phenomenon in metastatic carcinomas that can be used in new diagnostics strategies. Both, in the ovarian and endometrial cancer cells, LPA activates various signal transduction pathways, leading to the increased proliferation and metastatic abilities of the cells. In this review we would like to prove that development of potential treatment strategies by targeting LPA has a great promise in therapeutics.