Nocturnal Fat Oxidation and Metabolic Flexibility of Young Male Indian Adults Using Indirect Calorimetry

Srishti Sinha, R. Kuriyan
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引用次数: 1

Abstract

Indian adults tend to inappropriately accumulate body fat even at low Body Mass Index (BMI). Usually, fat that is stored in the fed state is mobilized for energy during nocturnal fasting, thus achieving daily fat balance. This is called metabolic flexibility, which may be lost in some individuals leading to body fat accumulation. Measuring fat balance requires 24h measurement of fat oxidation, but nocturnal fat oxidation could be a reasonable surrogate. The variability of nocturnal fat oxidation is also unknown. A retrospective analysis on 24h fat oxidation in adult men (n=18) was carried out to test the former hypothesis, while the variability of nocturnal fat oxidation was measured prospectively in 5 adult men, who were fed the same diet for 2 days prior to the measurement. Whole-body indirect calorimetry was used for measuring Respiratory Quotient (RQ), energy expenditure and fat oxidation. In 24h analyses, nocturnal (0.44 ± 0.21 g/kg) was significantly higher than diurnal fat oxidation (0.24 ± 0.21 g/kg) and was 64.5% of the total 24h value. Nocturnal fat oxidation was positively correlated with 24h fat oxidation (r = 0.937; p<0.01) and inversely correlated with 24h fat balance (r = -0.850; p<0.01). Metabolic flexibility, measured as the Fed: Fasted RQ ratio, was negatively correlated with BMI (r = -0.226; p=0.366). The intra- and inter-individual variability of 12h nocturnal fat oxidation was low, at 4.7% and 7.2%, respectively. Nocturnal fat oxidation has a low variability when prior diets over 2 days are constant and the Fed: Fasted RQ ratio is an index of metabolic flexibility, which relates to BMI in young adults.
使用间接量热法研究印度年轻男性成人夜间脂肪氧化和代谢灵活性
即使身体质量指数(BMI)很低,印度成年人也容易不适当地积累身体脂肪。通常,在夜间禁食时,储存在进食状态下的脂肪被动员起来作为能量,从而达到每日脂肪平衡。这被称为代谢灵活性,在一些人身上可能会失去这种灵活性,导致身体脂肪堆积。测量脂肪平衡需要24小时测量脂肪氧化,但夜间脂肪氧化可能是一个合理的替代方法。夜间脂肪氧化的可变性也是未知的。我们对成年男性(n=18)进行了24小时脂肪氧化的回顾性分析,以检验前一种假设,同时对5名成年男性的夜间脂肪氧化变异性进行了前瞻性测量,他们在测量前2天喂食相同的饮食。采用全身间接量热法测定呼吸商(RQ)、能量消耗和脂肪氧化。在24小时的分析中,夜间脂肪氧化(0.44±0.21 g/kg)显著高于白天脂肪氧化(0.24±0.21 g/kg),占24小时总值的64.5%。夜间脂肪氧化与24小时脂肪氧化呈正相关(r = 0.937;P <0.01),与24h脂肪平衡呈负相关(r = -0.850;p < 0.01)。代谢柔韧性,以禁食RQ比测量,与BMI呈负相关(r = -0.226;p = 0.366)。12小时夜间脂肪氧化的个体内部和个体间变异性较低,分别为4.7%和7.2%。当之前的饮食在2天内保持不变时,夜间脂肪氧化具有较低的可变性,并且禁食RQ比是代谢灵活性的指标,这与年轻人的BMI有关。
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