Detection of secondary dyslipidemia among people with «possible» familial hypercholesterolemia in Ukrainian population

Abstract

The aim – to optimize the diagnosis of familial hypercholesterolemia (FH) in Ukraine and determine the prevalence of secondary dyslipidemia among people with «possible» FH.Materials and methods. The work was carried out in two stages of population research. At the I stage (2009–2013), in 81 out of 1000 respondents (8.1 %) the level of LDL-C ≥ 5 mmol/l was registered. At the II stage (2019), additional survey of respondents was conducted to identify secondary dyslipidemia.Results and discussion. After additional examination of respondents with «possible» FH on II stage, type 2 diabetes was diagnosed in 20.4 %, hypothyroidism – in 14.3 %, class II–III obesity – in 16.3 %. In 30.6 % of respondents, the understudied comorbid pathology was not detected, and the level of LDL-C decreased on the background of lifestyle modification and statin therapy. The «possible» FH was finally verified in 9 patients with a burdened anamnesis of early coronary artery disease in them and/or their first-degree relatives, as well as with an increased LDL-C and total cholesterol levels on II stage, despite statin therapy.Conclusions. The percent of respondents with «possible» FH on the I stage, based only on criteria of LDL-C ³ 5 mmol/l, was 8.1 %. But after the detection of secondary dyslipidemia, the prevalence of verified FH within urban population was 0.9 %. In the rest cases (80 %), the elevated level of LDL-C was associated with comorbid pathology. The study proves the need for further optimization of the managment of patients with impaired lipid profile to verify primary and secondary hypercholesterolemia.