Nanoparticle preparation and characterization of Haruan fish ( Channa striata ) exctract contains albumin from south Kalimantan with ionic gelation method

International Journal of Drug Delivery Pub Date : 2017-10-06 DOI:10.5138/09750215.2070

D. Rahmawanty, A. Risa, N. Malikhatun, Prima Hr, K. Nani, A. Effionora

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引用次数: 1

Abstract

Snakehead fish ( Channa striata ) has been reported to be used for wound healing by people in South Borneo because it contains albumin. Snakehead fish extract ( Channa striata ) has hydrophillic property and poor stability. Nanoparticle technology has been started to be developed as an alternative solution to improve drug delivery profile. The purpose of this study was to determine the formulation that obtained best characterization for nanoparticle. Nanoparticles were prepared by ionic gelation method, that was prepared by doing optimize ratio between snakehead fish extract : chitosan and pH of chitosan solvent.Nanoparticles were characterized using Particle Size Analyzer for particle size and particle size distribution, measurement of entrapment efficiency, determined Zeta potential using Particle Size Analyzer, and observation of particle’s morphology using Transmission Electron Microscope. The result showed that the chosen formula was formula 6 which ratio of extract : chitosan 1:2 with chitosan solvent pH 3, particle size 152.3 nm, polidispersity index 0.778, percentage of entrapment efficiency 51.3961 %, Zeta potential +35.9 mV, and round shape of particles.

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离子凝胶法制备南加里曼丹白蛋白哈云鱼提取物及其表征

据报道，在南婆罗洲，人们用蛇头鱼(Channa striata)来治疗伤口，因为它含有白蛋白。黑鱼提取物具有亲水性，稳定性差。纳米颗粒技术已经开始发展，作为一种替代解决方案，以改善药物的输送。本研究的目的是确定获得最佳表征纳米颗粒的配方。采用离子凝胶法制备了纳米颗粒，优化了鱼头鱼提取物与壳聚糖的比例和壳聚糖溶剂的pH值。采用粒径分析仪对纳米颗粒进行了粒径和粒径分布的表征，测定了包封效率，测定了Zeta电位，透射电镜观察了纳米颗粒的形貌。结果表明:壳聚糖提取率为1:2，壳聚糖溶剂pH为3，粒径为152.3 nm，多分散度指数为0.778，包封率为51.3961%，Zeta电位+35.9 mV，颗粒形状为圆形。

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International Journal of Drug Delivery

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