THE MEASUREMENT AND CLINICAL SIGNIFICANCE OF NEURON-SPECIFIC ENOLASE IN PATIENTS WITH HEPATOENCEPHALOPATHY

Abstract

Objective:To study the clinical significance of neuron\|specific enolase (NSE) in the patients with hepatoencephalopathy(HE).Methods:The serum NSE was measured by ELISA in 46 cases.The results were analyzed in every clinical type liver disease and every stage of HE.Results:The serum NSE levels was significantly increased in the patients with HE (46.038±24.260) μg/L compared with the patients with chronic hepatitis (12.127±5.673) μg/L and control cases (10.196±3.237) μg/L.The serum NSE levels gradually increased (P0.05) in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis,and the serum NSE levels was obviously higher in patients with the fourth stage HE than they with first and second stage.Conclusion:The serume NSE levels obviously increased in the patients with HE,and it gradually increased in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis.The serum NSE levels were higher in the patients with more serious HE.