Quelles avancées en immunothérapie spécifique des maladies allergiques ?

A. Didier, L. Têtu, G. Prévot
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Abstract

Allergen immunotherapy remains the only etiologic treatment for allergic diseases. During this last decade significant progresses have occurred in the field of mechanism knowledge of allergen immunotherapy and in the search of new routes of administration or new types of formulation. On the other side, new vaccine development that exploits molecular engineering techniques may allow to create allergen extracts with specific target on the immune system. All of these should promote the use of allergen immunotherapy both by increasing the number of patients and by extending spectrum of indications of immunotherapy beyond allergic respiratory diseases. So, in the future, allergen immunotherapy should remain a corner stone in the management of allergy.

过敏性疾病特异性免疫反应的进展如何
过敏原免疫疗法仍然是过敏性疾病唯一的病因学治疗方法。在过去的十年中,在过敏原免疫治疗的机制知识和寻找新的给药途径或新型制剂方面取得了重大进展。另一方面,利用分子工程技术的新疫苗开发可能允许创建具有免疫系统特定目标的过敏原提取物。所有这些都应该通过增加患者数量和扩大免疫治疗的适应症范围来促进过敏原免疫治疗的使用,而不仅仅是过敏性呼吸道疾病。因此,在未来,过敏原免疫疗法应该仍然是过敏管理的基石。
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