{"title":"Prognostic value of free-water peritoneal clearance in decompensated cirrhosis: a 3 year prospective follow-up","authors":"Alessandro Milani, Antonella M. Ciammella, Marinella Mazzone, Adele Valle, Lodovico Rossi","doi":"10.1016/S0928-4346(97)00357-5","DOIUrl":null,"url":null,"abstract":"<div><p>Patients, 38, with decompensated cirrhosis were enrolled in a 3 year prospective follow-up to investigate the long-term prognostic value of free-water peritoneal clearance (FWPC) and intraabdominal pressure (IAP). All patients were ‘a priori’ divided into different subgroups, according to the basal values of FWPC (methylene-blue dilution method) and IAP (direct manometry). Arbitrarily chosen cut-off levels (90 ml/min for FWPC and 17 cm H<sub>2</sub>O for IAP) were adopted. The cumulative 3 year mortality was significantly lower in the subgroup of patients with FWPC above 90 ml/min than in those with FWPC below 90 ml/min (<em>P</em> < 0.05, Kaplan Meier method and log-rank test). No significant difference was found between the cumulated survivals of the subgroups discriminated by means of the IAP cut-off. Our results suggest that FWPC has an intrinsic prognostic value in patients with decompensated cirrhosis. Therefore, FWPC may be helpfully considered in a multivariate prognostic model for the estimate of the individual survivals in ascitic patients.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0928-4346(97)00357-5","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Hepatology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928434697003575","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Patients, 38, with decompensated cirrhosis were enrolled in a 3 year prospective follow-up to investigate the long-term prognostic value of free-water peritoneal clearance (FWPC) and intraabdominal pressure (IAP). All patients were ‘a priori’ divided into different subgroups, according to the basal values of FWPC (methylene-blue dilution method) and IAP (direct manometry). Arbitrarily chosen cut-off levels (90 ml/min for FWPC and 17 cm H2O for IAP) were adopted. The cumulative 3 year mortality was significantly lower in the subgroup of patients with FWPC above 90 ml/min than in those with FWPC below 90 ml/min (P < 0.05, Kaplan Meier method and log-rank test). No significant difference was found between the cumulated survivals of the subgroups discriminated by means of the IAP cut-off. Our results suggest that FWPC has an intrinsic prognostic value in patients with decompensated cirrhosis. Therefore, FWPC may be helpfully considered in a multivariate prognostic model for the estimate of the individual survivals in ascitic patients.