Validation of salivary glucose as a screening tool of diabetes mellitus

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
A. Choudhry, Pradeep Kumar, M. Prasad, T. Mohapatra, Preeti Sharma
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引用次数: 2

Abstract

Abstract Background: Improved prognosis and delay of clinical complications in diabetes mellitus can be ensured by early screening and regular monitoring after diagnosis. This requires venipuncture at regular intervals of time causing anxiety and discomfort to the patient. Hence, development of a painless, non-invasive procedure is desirable for which saliva is a potential tool. Also, this would provide easy and cost-effective means for large scale screening and epidemiological intervention. Aim: To measure fasting plasma glucose (FPG) and compare and correlate with salivary glucose levels in normal and diabetic individuals. Also, the correlation between glycated hemoglobin (HbA1c) and salivary glucose is studied in the diabetics and controls. Methods: Blood and salivary glucose was estimated by GOD-POD method and glycated hemoglobin by HPLC. Statistical analysis was done on SPSS 16. Mean, Standard deviation, independent t test, ANOVA (f test), Pearson’s correlation coefficient along with regression analysis was carried out and comparison was done between the control and diabetic groups and the different subgroups within the diabetic group. Results: A significant difference between the salivary glucose levels in subjects indicating that a deranged glycemic status is reflected in saliva. Also, salivary glucose increases in proportion to an increase in the FPG and HbA1C of the diabetics. The regression coefficient was calculated and a formula was derived for prediction of FPG and HbA1c using salivary glucose. Conclusion: Saliva can be used as a screening tool for diabetes. Standardization of the technique and setting up a reference range will also make it useful in diagnosing diabetes mellitus.
唾液葡萄糖作为糖尿病筛查工具的验证
摘要背景:通过早期筛查和诊断后的定期监测,可以改善糖尿病患者的预后,延缓其临床并发症的发生。这需要定期进行静脉穿刺,给患者带来焦虑和不适。因此,开发一种无痛、非侵入性的程序是可取的,唾液是一种潜在的工具。此外,这将为大规模筛查和流行病学干预提供简单和具有成本效益的手段。目的:测定正常人和糖尿病人的空腹血糖(FPG),比较其与唾液葡萄糖水平的相关性。此外,糖化血红蛋白(HbA1c)与唾液葡萄糖在糖尿病患者和对照组的相关性进行了研究。方法:用GOD-POD法测定血、唾液葡萄糖,用高效液相色谱法测定糖化血红蛋白。采用SPSS 16进行统计分析。采用均数、标准差、独立t检验、方差分析(f检验)、Pearson相关系数及回归分析,比较对照组、糖尿病组及糖尿病组内各亚组间的差异。结果:受试者唾液葡萄糖水平之间存在显著差异,表明血糖状态紊乱反映在唾液中。此外,糖尿病患者唾液葡萄糖的增加与FPG和HbA1C的增加成比例。计算回归系数,推导唾液葡萄糖预测FPG和HbA1c的公式。结论:唾液可作为糖尿病的筛查工具。技术的标准化和参考范围的建立也将有助于糖尿病的诊断。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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