Τhe Study of Square Periodic Perturbations as an Immunotherapy Process on a Tumor Growth Chaotic Model

Abstract

In the present study, the simulation of an immunotherapy effect for a known dynamical system, that describes the process for avascular, vascular, and metastasis tumor growth based on a chemical network model, has been presented. To this end, square signals of various amplitudes have been used, to model the effect of external therapy control, in order to affect the population of immune cells. The results of the simulations show that for certain values of the amplitude of the square signal, the populations of the proliferating tumor cells in the vascular and metastasis stages have been reduced.