Radiotherapy using a laser proton accelerator

M. Murakami, Y. Hishikawa, S. Miyajima, Y. Okazaki, K. Sutherland, M. Abe, S. V. Bulanov, H. Daido, T. Esirkepov, J. Koga, M. Yamagiwa, T. Tajima
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引用次数: 33

Abstract

Laser acceleration promises innovation in particle beam therapy of cancer where an ultra-compact accelerator system for cancer beam therapy can become affordable to a broad range of patients. This is not feasible without the introduction of a technology that is radically different from the conventional accelerator-based approach. The laser acceleration method provides many enhanced capabilities for the radiation oncologist. It reduces the overall system size and weight by more than one order of magnitude. The characteristics of the particle beams (protons) make them suitable for a class of therapy that might not be possible with the conventional accelerator, such as the ease for changing pulse intensity, the focus spread, the pinpointedness, and the dose delivery in general. A compact, uncluttered system allows a PET device to be located in the vicinity of the patient in concert with the compact gantry. The radiation oncologist may be able to irradiate a localized tumor by scanning with a pencil-like particle beam while ascertaining the actual dosage in the patient with an improved in-beam PET verification of auto-radioactivation induced by the beam therapy. This should yield an unprecedented flexibility in the feedback radiotherapy by the radiation oncologist. Laser accelerated radiotherapy has a unique niche in a current world of high energy accelerator using synchrotron or cyclotron.
使用激光质子加速器进行放射治疗
激光加速有望在癌症的粒子束治疗中实现创新,一种用于癌症束治疗的超紧凑加速器系统可以使广大患者负担得起。如果不引入一种与传统的基于加速器的方法截然不同的技术,这是不可行的。激光加速方法为放射肿瘤学家提供了许多增强的能力。它将整个系统的尺寸和重量减少了一个数量级以上。粒子束(质子)的特性使它们适合于传统加速器无法实现的一类治疗,例如易于改变脉冲强度、焦点扩散、精确定位和剂量传递。紧凑,整洁的系统允许PET装置与紧凑的龙门架一起放置在患者附近。放射肿瘤学家可能能够通过铅笔状粒子束扫描照射局部肿瘤,同时通过改进的束内PET验证束治疗诱导的自动放射来确定患者的实际剂量。这将在放射肿瘤学家的反馈放射治疗中产生前所未有的灵活性。激光加速放射治疗在目前使用同步加速器或回旋加速器的高能加速器中具有独特的地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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