The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7.
Anna Starzyńska, Aleksandra Sejda, Łukasz Adamski, Paulina Adamska, Rafał Pęksa, Monika Sakowicz-Burkiewicz, Piotr Wychowański, Barbara A Jereczek-Fossa
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引用次数: 0
Abstract
Introduction: The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases.
Aim: To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression.
Methods: A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review.
Results: The biggest study group consisted of 201 patients and the smallest - 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies.
Conclusions: The data presented indicate the complexity of cellular and molecular processes related to the formation, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma.
口腔最常见的恶性肿瘤是鳞状细胞癌。它占该地区恶性病变的95%以上，其特点是迅速扩散和远处转移。目的：收集和回顾B7家族蛋白在口腔鳞状细胞癌中作为预后因素的数据，并描述其在侵袭性疾病进展中的作用。方法：按照PRISMA （Preferred Reporting Items for systematic Reviews and meta - analysis）指南，对B7-1、B7-2、B7-H2、B7-H3、B7-H4、B7-H5 （VISTA）、B7-H6和B7-H7相关文献进行系统综述。在2020年5月22日之前发表的9篇文章被纳入系统评价。结果：最大研究组201例，最小研究组40例。B7-1、B7-H3、B7-H4、B7-H5、B7-H6、B7-H7蛋白表达是影响预后的因素。总生存率与B7-H3、B7-H5、B7-H6、B7-H7显著相关。所有研究均采用免疫组织化学诊断方法。结论：这些数据表明，口腔癌的形成、发展和侵袭具有复杂的细胞和分子过程。B7家族编码基因的突变和B7蛋白通路的改变可能影响口腔鳞状细胞癌患者的生存预后。
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