Psychological or physiological analgesics: A reconciliation

George Singer
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引用次数: 4

Abstract

Recently opiate receptors have been discovered in the central nervous system (CNS) which show specificity for opiate drugs as well as for a range of endogenous polypeptides. These endogenous opiates are released during stress and under those conditions have analgesic properties, also their peripheral injection leads to analgesia. In the present paper a common biochemical substrate which involves these polypeptides as an explanation of pharmacological and psychological analgesics is proposed. The evidence for this thesis is reviewed and further experimental tests are suggested.

心理或生理止痛剂:一种和解
近年来,在中枢神经系统(CNS)中发现了对阿片药物和一系列内源性多肽具有特异性的阿片受体。这些内源性阿片类药物在应激状态下释放,具有镇痛作用,同时外周注射可引起镇痛作用。在本文中,一个共同的生化底物涉及这些多肽作为解释药理学和心理镇痛提出。回顾了本论文的证据,并提出了进一步的实验验证建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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