An Energy-Based Complex Brain Network Model—Part 1: Local Electrophysiological Dynamics

Abstract

The human brain is a complex network of connected neurons whose dynamics are difficult to describe. Brain dynamics are the global manifestation of individual neuron dynamics and the synaptic coupling between neurons. Membrane potential is a function of synaptic dynamics and electrophysiological coupling, with the parameters of postsynaptic potential, action potential, and ion pump dynamics. By modelling synaptic dynamics using physical laws and the time evolution of membrane potential using energy, neuron dynamics can be described. This local depiction can be scaled up to describe mesoscopic and macroscopic hierarchical complexity in the brain. Modelling results are favorably compared with physiological observation and physically acquired action potential profiles as reported in the literature.