Arthrose et microbiote intestinal

Marie Binvignat , Harry Sokol , Encarnita Mariotti-Ferrandiz , Francis Berenbaum , Jérémie Sellam
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Abstract

The role of the intestinal microbiota within a “gut–joint” axis is increasingly studied in osteoarthritis. The intestinal microbiota, particularly via its role in low-grade systemic inflammation, could be involved in joint destruction and osteoarthritic pain. Its mechanisms of action in osteoarthritis remain complex, with, on the one hand, a direct action of intestinal dysbiosis on osteoarthritis involving systemic inflammation, and, on the other hand, an indirect effect via the promotion of metabolic syndrome and obesity. The published works in mice have mainly focused on the role of the intestinal microbiota in joint destruction in metabolic models of osteoarthritis. In humans, works have focused on indirect markers of the gut microbiota, such as lipopolysaccharide, or metabolites, such as tryptophan-derived ones. Also, intestinal dysbiosis could be one of the explanatory factors of osteoarthritic pain. A better understanding of the role of the intestinal microbiota in osteoarthritis could lead to the identification of new therapeutic targets.

关节和肠道微生物
在骨关节炎中,肠道微生物群在“肠-关节”轴中的作用越来越多地被研究。肠道微生物群,特别是通过其在低度全身性炎症中的作用,可能参与关节破坏和骨关节炎疼痛。其在骨关节炎中的作用机制仍然很复杂,一方面,肠道生态失调对骨关节炎的直接作用涉及全身性炎症,另一方面,通过促进代谢综合征和肥胖的间接作用。已发表的小鼠研究主要集中在骨关节炎代谢模型中肠道微生物群在关节破坏中的作用。在人类中,研究工作主要集中在肠道微生物群的间接标记物,如脂多糖,或代谢物,如色氨酸衍生的代谢物。此外,肠道生态失调可能是骨关节炎疼痛的解释因素之一。更好地了解肠道微生物群在骨关节炎中的作用可能会导致新的治疗靶点的确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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