White Matter and Disease: Does Brain have a Role in Initiating Diseases

Abstract

Several studies reported that the lesions of white matter (WMLs) are considered as asymptomatic lesions [7,8]. There are two types of WMLs. The first type is deep subcortical white matter (DSWMH), while the second type is periventricular (PVH) hyper-intensities. From a clinical point of view, WMLs have the potential of escalating the risk of ischemic stroke, dementia, and death [9,10]. WMLs are associated with different risk factors such as age, hypertension, diabetes, chronic kidney disease, and carotid stenosis [11-13].