Cortical structure in relation to empathy and psychopathy in 800 incarcerated men.

Marcin A Radecki, J Michael Maurer, Keith A Harenski, David D Stephenson, Erika Sampaolo, Giada Lettieri, Giacomo Handjaras, Emiliano Ricciardi, Samantha N Rodriguez, Craig S Neumann, Carla L Harenski, Sara Palumbo, Silvia Pellegrini, Jean Decety, Pietro Pietrini, Kent A Kiehl, Luca Cecchetti
{"title":"Cortical structure in relation to empathy and psychopathy in 800 incarcerated men.","authors":"Marcin A Radecki, J Michael Maurer, Keith A Harenski, David D Stephenson, Erika Sampaolo, Giada Lettieri, Giacomo Handjaras, Emiliano Ricciardi, Samantha N Rodriguez, Craig S Neumann, Carla L Harenski, Sara Palumbo, Silvia Pellegrini, Jean Decety, Pietro Pietrini, Kent A Kiehl, Luca Cecchetti","doi":"10.1101/2023.06.14.543399","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Reduced empathy is a hallmark of individuals with high psychopathy, who are overrepresented among incarcerated men. However, a comprehensive mapping of cortical structure in relation to empathy and psychopathy is lacking.</p><p><strong>Methods: </strong>In 804 incarcerated adult men, we administered the Perspective Taking (IRI-PT) and Empathic Concern (IRI-EC) subscales of the Interpersonal Reactivity Index, Hare Psychopathy Checklist-Revised (PCL-R; Interpersonal/Affective [F1] and Lifestyle/Antisocial [F2] factors), and T1-weighted MRI to quantify cortical thickness (CT) and surface area (SA). We also included the male sample from the Human Connectome Project (HCP; N = 501) to probe the replicability of structural-covariance gradients.</p><p><strong>Results: </strong>PCL-R F1 was uniquely negatively related to IRI-EC, while PCL-R F2 was uniquely negatively related to IRI-PT. Cortical structure was not related to either IRI subscale, although there was effect-size differentiation by cytoarchitectonic class and/or functional network. CT was related to PCL-R F1 (mostly positively), SA was related to both PCL-R factors (only positively), and both cortical indices demonstrated out-of-sample predictive utility for PCL-R F1. The high-psychopathy group (N = 178) scored uniquely lower on IRI-EC while having increased SA (but not CT); across the cortex, effect sizes were largest in the paralimbic class and somatomotor network, and meta-analytic task-based activations corroborated affective/sensory importance. Finally, the total sample revealed anterior-posterior gradients of covariance, which were replicated in the HCP sample. In the high-psychopathy group, the gradient of CT (but not SA) was globally compressed.</p><p><strong>Conclusions: </strong>Most notably, high-psychopathy men had reduced empathic concern, increased SA, and compressed macroscale organization of CT.</p>","PeriodicalId":72407,"journal":{"name":"bioRxiv : the preprint server for biology","volume":"11 suppl_1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996374/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv : the preprint server for biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2023.06.14.543399","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Reduced empathy is a hallmark of individuals with high psychopathy, who are overrepresented among incarcerated men. However, a comprehensive mapping of cortical structure in relation to empathy and psychopathy is lacking.

Methods: In 804 incarcerated adult men, we administered the Perspective Taking (IRI-PT) and Empathic Concern (IRI-EC) subscales of the Interpersonal Reactivity Index, Hare Psychopathy Checklist-Revised (PCL-R; Interpersonal/Affective [F1] and Lifestyle/Antisocial [F2] factors), and T1-weighted MRI to quantify cortical thickness (CT) and surface area (SA). We also included the male sample from the Human Connectome Project (HCP; N = 501) to probe the replicability of structural-covariance gradients.

Results: PCL-R F1 was uniquely negatively related to IRI-EC, while PCL-R F2 was uniquely negatively related to IRI-PT. Cortical structure was not related to either IRI subscale, although there was effect-size differentiation by cytoarchitectonic class and/or functional network. CT was related to PCL-R F1 (mostly positively), SA was related to both PCL-R factors (only positively), and both cortical indices demonstrated out-of-sample predictive utility for PCL-R F1. The high-psychopathy group (N = 178) scored uniquely lower on IRI-EC while having increased SA (but not CT); across the cortex, effect sizes were largest in the paralimbic class and somatomotor network, and meta-analytic task-based activations corroborated affective/sensory importance. Finally, the total sample revealed anterior-posterior gradients of covariance, which were replicated in the HCP sample. In the high-psychopathy group, the gradient of CT (but not SA) was globally compressed.

Conclusions: Most notably, high-psychopathy men had reduced empathic concern, increased SA, and compressed macroscale organization of CT.

800名被监禁男子的大脑皮层结构与共情和精神病的关系。
背景:情感共情减少是精神病的一个标志,它会导致重大的人际和社会成本。推进我们对这种减少和其他精神病特征的神经科学理解对于改善他们的治疗至关重要。方法:对804名在押成年男性进行了人际反应性指数的观点接受量表(IRI-PT)和共情关怀量表(IRI-EC),并对其进行了心理变态量表(PCL-R)的修订;两个因素),以及t1加权MRI量化皮质厚度(CT)和表面积(SA)。我们还纳入了人类连接组计划(HCP;N = 501)来复制宏观结构组织的模式。结果:因子1(人际/情感)与IRI-EC呈负相关,因子2(生活方式/反社会)与IRI-PT呈负相关。皮层结构与两个IRI分量表都没有关系,尽管存在微观结构类别和/或功能网络的效应大小分化。CT与因子1相关(大部分为正相关),SA与两个因素相关(仅为正相关),两个皮质指数都显示了因子1的样本外预测效用。高精神病态组(N = 178)在SA升高(但CT不升高)的同时,IRI-EC得分较低。从区域上看,这些SA的增加主要局限于旁边缘类和躯体运动网络,而基于元分析任务的激活证实了情感-感觉的重要性。高精神病患者在这两个皮层指数上也表现出“压缩”的全局和/或网络级组织,这种组织在HCP的总样本中得到了重复。所有的结果都与年龄、智商和/或总颅内容积有关。结论:精神病与情感共情呈负相关,与副边缘/躯体运动SA呈正相关,突出了情感和感觉的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信