Semi-quantitative analysis of the effect of 131I on residual thyroid tissue in patients with differentiated thyroid cancer

Q3 Medicine

中华地方病学杂志 Pub Date : 2019-06-20 DOI:10.3760/CMA.J.ISSN.2095-4255.2019.06.011

Jian Sun, Xinna Yuan, Yiping Zhao

{"title":"Semi-quantitative analysis of the effect of 131I on residual thyroid tissue in patients with differentiated thyroid cancer","authors":"Jian Sun, Xinna Yuan, Yiping Zhao","doi":"10.3760/CMA.J.ISSN.2095-4255.2019.06.011","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the effect of postoperative thyroid residual tissue on 131I treatment of differentiated thyroid carcinoma (DTC) metastases in patients with DTC. \n \n \nMethods \nPatients with thyroid residual tissue and lymph node metastases or distant organ metastases were confirmed by 131I whole body scan after 131I treatment of DTC from January 2004 to January 2013 in Dalian. The clinical data were divided into the cured group and the non-cured group according to the final results of 131I treatment. The per unit area count value (Kc/cm2) of residual thyroid remnant (NTR), lymph node metastases (LNM) and distant metastases (DM) were measured and performed semi-quantitative analysis. The thresholds of the analysis results were calculated by the Bootstrap method. \n \n \nResults \nA total of 114 patients were studied, aged from 14 to 80 years old, including 47 males and 67 females; the ratio of males to females was 1.0 ∶ 1.4. There were significant differences in NTR unit area counts (0.25 vs 1.29 Kc/cm2) between the cured group and the non-cured group (72 in the cured group and 42 in the non-cured group, U = 0.001, P 0.05). Those with the ratio of residual area to lymph node metastases (N/L) and the ratio of residual area to distant metastases (N/D) less than 1.7 had a better 131I treatment; unit area N/L greater than 4.9 and unit area N/D greater than 8.0 had a poor therapeutic effect. \n \n \nConclusion \nExcessive residual tissue after surgery results in poor efficacy of 131I treatment; semi-quantitative analysis for whole body scan after 131I treatment can predict the efficacy of 131I treatment. \n \n \nKey words: \nDifferentiated thyroid carcinoma; Residual thyroid remnant; Bootstrap","PeriodicalId":55880,"journal":{"name":"中华地方病学杂志","volume":"46 1","pages":"481-484"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华地方病学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.2095-4255.2019.06.011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To evaluate the effect of postoperative thyroid residual tissue on 131I treatment of differentiated thyroid carcinoma (DTC) metastases in patients with DTC. Methods Patients with thyroid residual tissue and lymph node metastases or distant organ metastases were confirmed by 131I whole body scan after 131I treatment of DTC from January 2004 to January 2013 in Dalian. The clinical data were divided into the cured group and the non-cured group according to the final results of 131I treatment. The per unit area count value (Kc/cm2) of residual thyroid remnant (NTR), lymph node metastases (LNM) and distant metastases (DM) were measured and performed semi-quantitative analysis. The thresholds of the analysis results were calculated by the Bootstrap method. Results A total of 114 patients were studied, aged from 14 to 80 years old, including 47 males and 67 females; the ratio of males to females was 1.0 ∶ 1.4. There were significant differences in NTR unit area counts (0.25 vs 1.29 Kc/cm2) between the cured group and the non-cured group (72 in the cured group and 42 in the non-cured group, U = 0.001, P 0.05). Those with the ratio of residual area to lymph node metastases (N/L) and the ratio of residual area to distant metastases (N/D) less than 1.7 had a better 131I treatment; unit area N/L greater than 4.9 and unit area N/D greater than 8.0 had a poor therapeutic effect. Conclusion Excessive residual tissue after surgery results in poor efficacy of 131I treatment; semi-quantitative analysis for whole body scan after 131I treatment can predict the efficacy of 131I treatment. Key words: Differentiated thyroid carcinoma; Residual thyroid remnant; Bootstrap

查看原文本刊更多论文

131I对分化型甲状腺癌患者残留甲状腺组织影响的半定量分析

目的探讨分化型甲状腺癌(DTC)转移患者术后甲状腺残留组织在131I治疗中的作用。方法对2004年1月至2013年1月在大连市经131I治疗的DTC患者，经131I全身扫描确认有甲状腺残留组织、淋巴结转移或远处器官转移。根据131I治疗的最终结果，将临床资料分为治愈组和未治愈组。测量甲状腺残余(NTR)、淋巴结转移(LNM)和远处转移(DM)的单位面积计数值(Kc/cm2)并进行半定量分析。采用Bootstrap方法计算分析结果的阈值。结果共114例患者，年龄14 ~ 80岁，其中男性47例，女性67例;男女比例为1.0∶1.4。治疗组与未治疗组的NTR单位面积计数(0.25 vs 1.29 Kc/cm2)差异有统计学意义(治疗组72 Kc/cm2，未治疗组42 Kc/cm2, U = 0.001, P 0.05)。残余面积与淋巴结转移之比(N/L)和残余面积与远处转移之比(N/D)均小于1.7者，131I治疗效果较好;单位面积N/L大于4.9和单位面积N/D大于8.0治疗效果较差。结论术后残留组织过多导致131I治疗效果不佳;131I治疗后全身扫描的半定量分析可以预测131I治疗的疗效。关键词:分化型甲状腺癌;甲状腺残体;引导

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.