Advances in Transdermal Drug Delivery System

Abstract

applications. In TDDS, nanoparticles could significant-ly improve the penetration of macromolecular drugs across the stratum corneum, with the po-tential to reduce immunogenicity and improve the bioavailability. The most common nanoparticles used TDDS are self-assembled liposomes, solid-li-pid nanoparticles, polymeric micelles, and inorganic nanoparticles. Compared with organic nanoparticles, inorganic nanoparticles offer higher physiochemical stability, easier surface functional-ization, and possess a tunable particle size and varied morphology. Thus, developing novel transdermal nanodevices based on inorganic nanoparticles is one of the fastest growing fields in nano-medicine.