The Effect of the Bicyclononan Derivative on the Conditioned Reflex of Passive Avoidance in Rats with Cerebral Ischemia

Abstract

The aim of this study was to develop the effect of substance Z–109 a bicyclononan derivative, presumably belonging to the class of ampakines on the memory of rats undergoing cerebral ischemia. The evaluation of mnestic functions was carried out on the model of the conditioned passive avoidance reflex. Ischemic brain damage was reproduced by 200 in rats of both sexes occlusion of the middle cerebral artery, photoinduced thrombosis in the prefrontal cortex, complete ligation of both carotid arteries. The test substance was found to have a positive effect at doses of 2.5 mg / kg, 13 mg/kg and 25 mg / kg in the treatment of various types of ischemic brain damage, the substance had a maximum effect at a dose of 2.5 mg / kg. The investigated substance is possible for prospective study as a neuroprotective anti-stroke agent.