Preparation and evaluation of polyherbal formulation for its antidiabetic activity against streptozotocin induced diabetes rat model

Abstract

Objective: The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal Albino wistar rats and study the antdiabetic activity of polyherbal formulation by comparison of changes in levels of glucose between normal and diabetic rats . Methods: The effect of methanol extract of poly herbal preparation containing aerial parts of Schrebera swietenoides, roots of Barleria montana and aerial parts of Rotula aquatica was investigated in normal and streptozotocin induced diabetic rats. Results: The lowest blood glucose levels were observed at 4 and 8 th hr after the oral administration of 150 and 300 mg/kg b.w polyherbal formulation. The blood glucose levels at 24hrs after the oral administration of 150 and 300 mg/kg b. w of poly herbal formulation was significantly lowers the blood glucose levels. Conclusions: The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations.