{"title":"Measles: What we have learned from non-human primate models","authors":"Rik L. de Swart","doi":"10.1016/j.ddmod.2018.01.002","DOIUrl":null,"url":null,"abstract":"<div><p>Studies in non-human primates (NHPs) have been crucial for our understanding of measles as a high impact viral disease of humans. Over a century ago, inoculations of NHPs with filtered secretions from measles patients first identified a virus as the causative agent of this disease. In the 1960s, studies in NHPs with measles virus isolates passaged <em>in vitro</em> provided the basis for live-attenuated measles virus vaccines, which became one of the most successful medical interventions in history. More recently, experimental infections of NHPs have provided critical contributions to our understanding of the tropism and pathogenesis of measles virus. This review briefly highlights some of the lessons learned from NHP models of measles virus infection.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2018.01.002","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675717300361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 7
Abstract
Studies in non-human primates (NHPs) have been crucial for our understanding of measles as a high impact viral disease of humans. Over a century ago, inoculations of NHPs with filtered secretions from measles patients first identified a virus as the causative agent of this disease. In the 1960s, studies in NHPs with measles virus isolates passaged in vitro provided the basis for live-attenuated measles virus vaccines, which became one of the most successful medical interventions in history. More recently, experimental infections of NHPs have provided critical contributions to our understanding of the tropism and pathogenesis of measles virus. This review briefly highlights some of the lessons learned from NHP models of measles virus infection.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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