Increased levels of hope are associated with slower rates of relapse following detoxification among people living with opioid dependence

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
H. Reddon, J. Ivers
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引用次数: 0

Abstract

Abstract Background The present study was conducted to estimate the association between measures of hope for the future and time to substance use relapse among people living with opioid dependence following their discharge from opioid detoxification programs. Method The data for this investigation were collected from a prospective cohort study of patients who completed detoxification in Ireland (N = 142). After baseline, participants completed follow-up visits at three, six and nine months. Cox regression models were used to analyze the association between measures of hope and time to relapse. Results Of the 142 participants included in this study, 43 (30.3%) were female and the mean duration of substance use was 14.3 years (standard deviation: 5.8). In the multivariable analysis, a five-unit increase in mean Trait Hope Scale scores was associated with a mean decrease of 23% in the Hazard Ratio (HR) of relapse following detoxification (HR = 0.77, 95% Confidence Interval [CI]: 0.63–0.94; p = 0.011). In the sub-analysis, the hope-agency subdomain was significantly associated with lower rates of relapse (HR = 0.59, 95% CI: 0.41–0.83; p = 0.009), while the hope-pathway subdomain was not significantly associated with relapse rates (HR = 0.74, 95% CI: 0.50–1.11; p = 0.146). Conclusions In the present study, increased mean levels of hope were associated with slower rates of relapse among people living with opioid dependence following discharge from detoxification programs. These findings suggest that empowering people in recovery and providing additional support following services such as detoxification may be valuable strategies to reduce relapse rates among people living with opioid dependence.
在阿片类药物依赖者中,希望水平的提高与戒毒后复发率的降低有关
摘要背景本研究旨在评估阿片类药物依赖者在阿片类药物解毒后对未来的希望与药物使用复发时间之间的关系。方法本研究的数据收集自爱尔兰完成戒毒的患者的前瞻性队列研究(N = 142)。基线后,参与者分别在3个月、6个月和9个月完成随访。采用Cox回归模型分析希望指标与复发时间之间的关系。结果142例患者中,女性43例(30.3%),平均药物使用时间14.3年(标准差:5.8)。在多变量分析中,特质希望量表平均得分每增加5个单位,戒毒后复发的危险比(HR)平均降低23% (HR = 0.77, 95%可信区间[CI]: 0.63-0.94;p = 0.011)。在亚分析中,希望-代理子域与较低的复发率显著相关(HR = 0.59, 95% CI: 0.41-0.83;p = 0.009),而希望途径子域与复发率无显著相关(HR = 0.74, 95% CI: 0.50-1.11;p = 0.146)。在目前的研究中,增加的平均希望水平与阿片类药物依赖者在戒毒项目出院后复发率较低有关。这些发现表明,增强康复者的权能,并在戒毒等服务后提供额外支持,可能是降低阿片类药物依赖者复发率的宝贵策略。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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