Biomimic Antibacterial Sensing Silk Bio-Patch

Abstract

We report a class of biomimic silk-based bio-patches with inherent bacterial inhibition and infection monitoring function. Mechanical properties of the silk bio-patch can be well-tuned to match the elastic modulus of human patches such as dura mater and hernia patch. The silk bio-patch can be functionalized by facilely adding bioactive drugs and bio-factors. Bacterial inhibition can be achieved by the micro-patterns of the optical diffraction element (DOE) on the silk bio-patch. Besides, the DOE in the silk bio-patch can be used to monitor tissue infection by detecting the change of the diffraction pattern. Our approach offers potential to developing multifunctional implantable devices in biomedical applications.