Age and fertility

Primary care update for Ob/Gyns Pub Date : 2003-11-01 DOI:10.1016/S1068-607X(03)00066-0

Rajeevi Madankumar MD , Matthew A Cohen MD , Steven H Brenner MD

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引用次数: 28

Abstract

More women are planning pregnancy after the age of 35. Unfortunately for these individuals, aging is associated with compromised ovarian function and decreasing fecundity. Compromised oocyte quality is associated with fetal aneuploidies and poor quality embryos with an increased miscarriage rate. Secondary to this compromised oocyte quality, success rates of assisted reproductive techniques decline. Follicle stimulating hormone (FSH) and estradiol levels on day 3 of the menstrual cycle help to assess the ovarian reserve. Fertility potential can also be assessed by the clomiphene challenge test. In order for women to plan for their childbearing, an understanding of the influence of age on fertility is essential. It is the responsibility of caregivers to educate patients regarding this issue. Assisted reproductive techniques (ART), ovum donation, and preimplantation diagnostic techniques help to improve the successful pregnancy outcomes in older women.

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年龄和生育能力

越来越多的女性计划在35岁以后怀孕。不幸的是，对于这些人来说，衰老与卵巢功能受损和生育能力下降有关。卵母细胞质量受损与胎儿非整倍体和质量差的胚胎有关，流产率增加。其次是卵母细胞质量受损，辅助生殖技术的成功率下降。卵泡刺激素(FSH)和雌二醇水平在月经周期的第3天有助于评估卵巢储备。生育潜力也可以通过克罗米芬激发试验来评估。为了使妇女计划生育，了解年龄对生育能力的影响是至关重要的。护理人员有责任就这一问题教育患者。辅助生殖技术(ART)、卵子捐赠和着床前诊断技术有助于提高老年妇女的成功妊娠结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Primary care update for Ob/Gyns

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