Is Trimethoprim-Sulfamethoxazole (TMP-SMX) An Alternative in the Management of Infections by Community-Acquired Methicillin Resistant Staphylococcus aureus in Children?

Abstract

Although we did not exclude studies according to the location and severity of infections, no studies on invasive infections treated with TMP-SMX that met high grade of evidence was found. All the studies included were focused on skin and soft-tissue infections, which are the most common CA-MRSA-related infections. In other infections the role of TMP-SMX is not clearly defined. Its use in the treatment of invasive infections has been discouraged because of a concern for therapeutic failures.