Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats

International Journal of Food Science and Biotechnology Pub Date : 2019-10-09 DOI:10.11648/j.ijfsb.20190403.12

R. M. Ibrahim, Fatma El Zahraa Ali Abd Elaal, S. Zaki

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引用次数: 6

Abstract

Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3- curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and 15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same side, the treatment with AlCl3 alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl3-treated rats.

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姜黄素和纳米姜黄素对大鼠铝毒性的影响

铝是一种普遍存在的有毒金属，主要影响脑、骨、脾、肝、肾、肝造血系统。本研究探讨了姜黄素和姜黄素纳米颗粒对降低氯化铝中毒大鼠的作用。采用六组大鼠:(1)对照组;(2)姜黄素处理大鼠(15 mg姜黄素/Kg BW;(3)纳米姜黄素处理大鼠(15 mg纳米姜黄素/Kg BW);(4)氯化铝处理大鼠(100 mg/kg BW);(5) AlCl3-姜黄素处理大鼠(100 mg AlCl3和15 mg姜黄素/kg BW);(6) AlCl3-纳米姜黄素处理大鼠(100 mg AlCl3和15 mg纳米姜黄素/kg BW)。单用AlCl3治疗大鼠肝肾功能显著(P≤0.05)升高，而口服姜黄素和纳米姜黄素可消除AlCl3的有害作用。另一方面，AlCl3单独处理显著(P≤0.05)增加了血浆中自由基水平，降低了血浆中抗氧化酶的活性，而姜黄素和纳米姜黄素处理则降低了血浆中自由基的增加，提高了血浆中抗氧化酶的活性。这些结果证实姜黄素和纳米姜黄素降低了AlCl3对大鼠的毒性作用;此外，纳米姜黄素对健康大鼠和alcl3处理大鼠的生物活性和抗氧化活性均优于姜黄素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Food Science and Biotechnology

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