Transformation of monoclonal B lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma.

IF 0.2

AJSP-Reviews and Reports Pub Date : 2019-09-01 DOI:10.1097/PCR.0000000000000326

Y. Liu, Caleb Ho, M. Roshal, Jeeyeon Baik, M. Arcila, Yanming Zhang, A. Dogan, Wenbin Xiao

引用次数: 0

Abstract

Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome (RS), usually includes diffuse large B-cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). The transformation can be clonally related to the underlying CLL, and is often Epstein-Barr virus (EBV)-associated. Here we report an 86-year-old female with a newly identified CLL-like monoclonal B-lymphocytosis (MBL) who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between DLBCL and CHL, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetics and molecular studies demonstrate a clonal relatedness that suggests a transformation from MBL to EBV+ gray zone lymphoma.

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单克隆B淋巴细胞增多症向Epstein-Barr病毒阳性大B细胞淋巴瘤转化，其特征介于弥漫性大B细胞淋巴瘤和典型霍奇金淋巴瘤之间。

慢性淋巴细胞白血病(CLL)转化为侵袭性淋巴瘤，即所谓的Richter综合征(RS)，通常包括弥漫性大b细胞淋巴瘤(DLBCL)和经典霍奇金淋巴瘤(CHL)。这种转化可以与潜在的CLL无性相关，并且通常与eb病毒(EBV)相关。在这里，我们报告一位86岁的女性，新发现的cll样单克隆b淋巴细胞增多症(MBL)发展为弥漫性淋巴结病。左腋窝淋巴结活检显示ebv阳性大b细胞淋巴瘤，形态学和免疫表型特征介于DLBCL和CHL之间，即所谓的灰色地带淋巴瘤。综合免疫表型、细胞遗传学和分子研究表明，克隆相关性表明从MBL到EBV+灰色地带淋巴瘤的转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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AJSP-Reviews and Reports PATHOLOGY-

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期刊介绍： Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.