UJI FORMULASI SEDIAAN SALEP EKSTRAK ETANOL DAUN PACAR (Lawsonia inermis L.) TERHADAP BAKTERI Staphylococcus aureus DAN Pseudomonas aeruginosa

Jurnal Penelitian Farmasi & Herbal Pub Date : 2021-10-31 DOI:10.36656/jpfh.v4i1.767

Nina Irmayanti Harahap

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Abstract

Background: Indonesia is a country rich in natural resources that can be used as traditional medicine. Pacar leaf extract (Lawsonia inermis L.) can be formulated into ointment preparations, can inhibit the growth of staphylococcus aureus (SA) and pseudomonas aeruginosa (PA) bacteria and determine the best inhibitory concentration. Methods: This research method was experimental, the extract was obtained by maceration method with 80% ethanol solvent, then ointment was made using adeps lanae base, vaseline album and Pacar leaf extract ointment hadcombination concentrations 8%, 12% and 16%. The results of the study: The results showed that Pacar Leaf Extract (SEEDP)could be formulated as an ointment preparation and met the requirements for quality testing of ointment preparations, including characterization tests and phytochemical screening tests. The results of the antibacterial activity test showed that the formulation of the ointment preparations of Pacar Extract with concentrations of 8%, 12% and 16% could inhibit the growth of bacteria and good inhibition of 16% with an average diameter of bacteria (SA). 11.93 mm and bacteria (PA) 17.2 mm.It was concluded that the higher the concentration of the extract, the greater the inhibition given. The preparation of pacar leaf extract ointment with concentrations of 8%, 12% and 16% was the best ointment in inhibiting the growth of bacteria (SA) and (PA)

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男友叶子乙醇萃取膏膏配方试验。抗菌菌和铜绿假单胞菌

背景:印度尼西亚是一个自然资源丰富的国家，可以作为传统药物使用。Pacar叶提取物(Lawsonia inermis L.)可配制成软膏制剂，可抑制金黄色葡萄球菌(SA)和铜绿假单胞菌(PA)细菌的生长并确定最佳抑制浓度。方法:本研究采用实验方法，用80%乙醇溶剂浸渍法制备提取液，然后用阿普斯兰碱、凡士林影集和帕卡叶提取物配制软膏，其组合浓度分别为8%、12%和16%。研究结果表明:Pacar叶提取物(SEEDP)可配制为软膏制剂，满足软膏制剂的质量检测要求，包括表征试验和植物化学筛选试验。抗菌活性试验结果表明，Pacar提取物浓度为8%、12%和16%的软膏制剂均能抑制细菌的生长，平均细菌直径(SA)的抑制率为16%。细菌(PA)为17.2 mm。结果表明，提取物浓度越高，抑菌效果越好。对细菌(SA)和(PA)生长抑制效果最好的药膏分别为8%、12%和16%。

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Jurnal Penelitian Farmasi & Herbal

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