Medical Management in Focal versus Generalized Epilepsy

IF 0.2 Q4 PEDIATRICS
Kumar Sannagowdara, N. Khan
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引用次数: 1

Abstract

Abstract About 70% of children with new-onset epilepsy have the potential to become seizure-free on antiepileptic drug (AED) monotherapy with appropriately selected first-line medication. In ideal world, physician is expected to achieve best possible seizure control without impacting the quality of life. There is rapid increase in number of AEDs available over last couple of decades. Although not necessarily all of them are superior to old generation drugs in terms of seizure control, certainly there is change in landscape from perspective of tolerability and side-effect profile. Physicians must therefore be familiar with safety, tolerability, therapeutic effects, synergistic combinations as well as AEDs to avoid in specific circumstances. The article attempts to give general overview of available AEDs under broad umbrella of effectiveness against focal and generalized seizures as well as drugs with “broad spectrum.” The emergence of newer AEDs with broad spectrum and favorable side-effect profile is welcome. However, the future lies in better understanding of underlying diverse pathophysiology of clinical symptom “epilepsy” and developing new compounds acting on molecular targets as well as individualizing therapy. Technological advances in molecular genetics research are bringing precision medicine to the fore.
局灶性癫痫与全身性癫痫的医疗管理
约70%的新发癫痫患儿接受抗癫痫药物单药治疗,并适当选择一线药物,有可能实现无癫痫发作。在理想情况下,医生被期望在不影响生活质量的情况下实现最好的癫痫控制。在过去几十年里,可用的aed数量迅速增加。虽然并非所有的药物在控制癫痫发作方面都优于老一代药物,但从耐受性和副作用的角度来看,肯定会发生变化。因此,医生必须熟悉安全性、耐受性、治疗效果、协同组合以及在特定情况下避免使用aed。本文试图对抗局灶性和全面性癫痫发作以及“广谱”药物的有效性进行概述。具有广谱和良好副作用的新型aed的出现是受欢迎的。然而,未来在于更好地了解临床症状“癫痫”的潜在多种病理生理,开发作用于分子靶点的新化合物以及个体化治疗。分子遗传学研究的技术进步将精准医学带到了前台。
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来源期刊
自引率
0.00%
发文量
21
期刊介绍: The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.
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