A speculative discussion of four animal carcinogens endogenously produced in humans and a formula for cancer development

Abstract

The major factors (macro) which cause human cancer have been elucidated and include tobacco use, diet, infection, reproductive and sexual behavior and, to a lesser extent, alcohol consumption and occupational factors. Several reports have been published about endogenous chemicals made in humans which produce DNA adducts; however, few have linked them to possible carcinogenic activity. This paper discussed four chemicals made in humans (formaldehyde, acetaldehyde, isoprene and ethylene oxide), pathways of their formation, their animal carcinogenicity and questions about these and other endogenous chemicals’ possible role in human cancer. In addition, the author posits a simplified formula for development of cancer and a formula for causing mutations by various agents.