In Silico Study of α-Amylase and α-Glucosidase Inhibitory Compounds in Aloe vera as Antidiabetic Agent

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease that poses a significant global health issue. Acarbose is a commonly given drug to treat diabetes, which works as an inhibitor of polysaccharide-degraded enzymes. However, acarbose has side effects that cause indigestion, diarrhea, flatulence, nausea, and vomiting. On the other hand, Aloe vera contains compounds that have been proven to have antidiabetic activity by reducing glucose levels in the blood and increasing insulin production and sensitivity to insulin by in vitro study.