Polymorphisms in the survivin gene and the risk of lung cancer

Abstract

Objective To explore the relationship between 9194A/G polymorphism of survivin gene and lung cancer, and whether it is related to smoking factors. Methods From March 2011 to April 2012, 133 lung cancer patients from the Second Affiliated Hospital of Harbin Medical University were selected as the lung cancer group and 150 healthy people as the control group.By the case-control study method, polymerase chain reaction-restriction fragment length polymorphism method was used for analyzing the 9194A/G polymorphism of survivin gene in peripheral blood samples.Further stratified analysis according to smoking degree. Results The genotype frequencies of 9194A/G of survivin gene for 9194AA, 9194AG, and 9194GG were 61.33%, 33.33%, and 5.33% in the control group, and 64.66%, 30.83%, and 4.51% in the lung cancer group.There was no statistical difference between the two groups (χ2=0.358, P=0.836). There was no significant difference in the composition of survivin gene 9194A/G between lung cancer group and control group under different smoking conditions (all P>0.05). Conclusions There may be no association between the 9194A/G polymorphism of survivin gene and the lung cancer.There was no significant association between the 9194A/G polymorphism of survivin gene and smoking. Key words: Lung neoplasms; Smoking; Gene polymorphism; survivin