Therapeutic Effect of Asphodelus Tenuifolius Against Streptozotocin Induced Diabetic Rats

American Journal of Surgery and Clinical Case Reports Pub Date : 2022-01-01 DOI:10.47829/ajsccr.2022.6102

Khadeejah Rana, H. S

{"title":"Therapeutic Effect of Asphodelus Tenuifolius Against Streptozotocin Induced Diabetic Rats","authors":"Khadeejah Rana, H. S","doi":"10.47829/ajsccr.2022.6102","DOIUrl":null,"url":null,"abstract":"Background: Diabetes mellitus is a long-lasting metabolic disorder that hinders the capability of the body to utilize food properly and is affected day by day through our diet, exercise, infection and stress. Presently, the trend is more towards natural plant-based products containing potential bio-active components than towards conventional medicines. For the purpose, out of numerous herbs used in common medicines, the subfamily of Asphodelus tenuifolius, used for several ailments, anti-inflmmation, anti-hypertension and antidiuretics etc. Objective: The objective of the present study was to evaluate the therapeutic effect of Asphodelus tenuifolius against streptozotocin induced diabetic rats. Method: The current study was based on the in vitro and in vivo properties of Asphodelus tenuifolius. The in vivo study was conducted that includes the TPC, TFC & DPPH. The in vitro study was also administered that includes the body weight and glucose levels of the rats. The thirty rats were divided into six groups; normal control, disease control, drug control, extracts treatment at 250, 500 and 750 mg/kg respectively. Results: The results depicted that the maximum decline in blood glucose levels of the streptozotocin induced diabetic rats were observed in T5. However, the body weights of the diabetic rats were maintained. Conclusion: Conclusively, Asphodelus tenuifolius plants contain a bio-active component that help to reduce hyperglycemia, maintains body weights in streptozotocin induced diabetic rats.","PeriodicalId":7649,"journal":{"name":"American Journal of Surgery and Clinical Case Reports","volume":"42 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Surgery and Clinical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47829/ajsccr.2022.6102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Diabetes mellitus is a long-lasting metabolic disorder that hinders the capability of the body to utilize food properly and is affected day by day through our diet, exercise, infection and stress. Presently, the trend is more towards natural plant-based products containing potential bio-active components than towards conventional medicines. For the purpose, out of numerous herbs used in common medicines, the subfamily of Asphodelus tenuifolius, used for several ailments, anti-inflmmation, anti-hypertension and antidiuretics etc. Objective: The objective of the present study was to evaluate the therapeutic effect of Asphodelus tenuifolius against streptozotocin induced diabetic rats. Method: The current study was based on the in vitro and in vivo properties of Asphodelus tenuifolius. The in vivo study was conducted that includes the TPC, TFC & DPPH. The in vitro study was also administered that includes the body weight and glucose levels of the rats. The thirty rats were divided into six groups; normal control, disease control, drug control, extracts treatment at 250, 500 and 750 mg/kg respectively. Results: The results depicted that the maximum decline in blood glucose levels of the streptozotocin induced diabetic rats were observed in T5. However, the body weights of the diabetic rats were maintained. Conclusion: Conclusively, Asphodelus tenuifolius plants contain a bio-active component that help to reduce hyperglycemia, maintains body weights in streptozotocin induced diabetic rats.

查看原文本刊更多论文

细藤对链脲佐菌素诱导的糖尿病大鼠的治疗作用

背景:糖尿病是一种长期存在的代谢性疾病，它阻碍了人体合理利用食物的能力，并日复一日地受到我们的饮食、运动、感染和压力的影响。目前的趋势是更倾向于含有潜在生物活性成分的天然植物性产品，而不是传统药物。为了达到这一目的，在常用药物中使用的众多草药中，细叶黄亚科用于几种疾病，抗炎，降压和抗利尿剂等。目的:探讨细藤对链脲佐菌素诱导的糖尿病大鼠的治疗作用。方法:本研究是在对细叶仙的体内外特性进行研究的基础上进行的。进行了包括TPC、TFC和DPPH在内的体内研究。体外研究也进行了，包括大鼠的体重和血糖水平。将30只大鼠分为6组;正常对照组、疾病对照组、药物对照组、提取物治疗分别为250、500和750 mg/kg。结果:链脲佐菌素诱导的糖尿病大鼠在T5时血糖下降幅度最大。然而，糖尿病大鼠的体重保持不变。结论:在链脲佐菌素诱导的糖尿病大鼠实验中，细叶茅含有降低高血糖、维持体重的生物活性成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Surgery and Clinical Case Reports

自引率

0.00%

发文量