Giant cell glioblastoma in childhood-Pathohistological and immunohistochemical analysis, forecast and complex treatment

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Abstract

A six year old child is presented with giant cell glioblastoma multiforme. The importance of pathohistological and immunohistochemical analysis is discussed for the diagnosis of this rare pathohistological subtype glioblastoma in childhood. The Magnetic Resonance Image Characteristics, unfavorable prognosis and high cancer cell resistance to radiotherapy (RT) and chemotherapy (Ch) are also highlighted. The risk of local recurrences and tumor progression is high, despite the complex treatment, including visibly total tumor surgery, postoperative RT and adjuvant Ch. By this pediatric clinical case of childhood giant cell glioblastoma multiforme, we emphasize the emerging need to optimize early diagnostics and the multidisciplinary healing approach.
儿童巨细胞胶质母细胞瘤的病理组织学和免疫组织化学分析、预测和综合治疗
一个六岁的儿童患有多形性巨细胞胶质母细胞瘤。病理组织学和免疫组织化学分析的重要性,以诊断这种罕见的病理组织学亚型胶质母细胞瘤在儿童。同时也强调了其磁共振影像特征、不良预后及肿瘤细胞对放疗和化疗的高耐药性。尽管治疗复杂,包括明显的全肿瘤手术、术后RT和辅助Ch,但局部复发和肿瘤进展的风险很高。通过这例儿童多形性巨细胞胶质母细胞瘤的临床病例,我们强调需要优化早期诊断和多学科治疗方法。
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