Impact of interstitial lung disease on postoperative morbidity and 60 day mortality after pulmonary resection for lung cancer

Weipeng Shao, Jingjing Huang, J. Zhang, Shanwu Ma, Hongxiang Feng, Hongliang Sun, Yanhong Ren, Xiaowei Wang, Zhen-rong Zhang, Deruo Liu
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Abstract

Objective To evaluate the effect of interstitial lung disease(ILD) on postoperative morbidity and mortality in pulmonary resection for lung cancer patients. Methods We retrospectively analyzed 971 patients undergoing pulmonary operation from January 2010 to January 2018 in our hospital. Clinical data including age, sex, history of chronic obstructive pulmonary disease(COPD), smoking history, smoking index, American Society of Anesthesiologists(ASA) classification, forced expiratory volume in 1 s(FEV1) % predict, surgical procedure, video assisted thoracoscopic surgery(VATS) or not, intraoperative blood transfusion, anesthesia time, operation time/one-lung ventilation time, blood loss, histology, postoperative morbidity, 60-days mortality, onset of acute exacerbation of interstitial lung disease(AE-ILD), drainage, extubation time, and postoperative stay were collected and analyzed. Results There were 80(8.2%) and 891(91.8%) patients in ILD and non-ILD group, respectively. AE-ILD occurred in 5 patients, with a 60-day mortality of 80%. A multivariate regression analysis identified that the sex(P=0.023), ILD(P=0.001), COPD(P=0.027) were independent risk factors for postoperative morbidity. ILD(P=0.023) and postoperative morbidity(P=0.001) were independent risk factors for 60-day mortality in multivariate analysis. Conclusion Patients with ILD had a higher incidence of postoperative morbidity and 60-day mortality. Based on the obvious postoperative morbidity and mortality, special attention and management should be taken in ILD patients. Key words: ILD; Pulmonary resection; AE-ILD; Morbidity; 60-day mortality
间质性肺疾病对肺癌肺切除术后术后发病率和60天死亡率的影响
目的探讨间质性肺疾病(ILD)对肺癌肺切除术患者术后发病率和死亡率的影响。方法回顾性分析2010年1月至2018年1月在我院行肺部手术的971例患者。临床资料包括年龄、性别、慢性阻塞性肺疾病(COPD)史、吸烟史、吸烟指数、美国麻醉医师学会(ASA)分级、用力呼气量在1秒内(FEV1) %预测、手术方式、视频辅助胸腔镜手术(VATS)与否、术中输血、麻醉时间、手术时间/单肺通气时间、出血量、组织学、术后发病率、60天死亡率、收集并分析间质性肺疾病急性加重(AE-ILD)的发病、引流、拔管时间和术后住院时间。结果ILD组80例(8.2%),非ILD组891例(91.8%)。5例患者发生AE-ILD, 60天死亡率为80%。多因素回归分析发现,性别(P=0.023)、ILD(P=0.001)、COPD(P=0.027)是术后发病率的独立危险因素。多因素分析显示,ILD(P=0.023)和术后发病率(P=0.001)是60天死亡率的独立危险因素。结论ILD患者术后发病率和60天死亡率较高。基于术后明显的发病率和死亡率,ILD患者应特别重视和处理。关键词:ILD;肺切除术;AE-ILD;发病率;60天的死亡率
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