Stability Constant Study of Transition Metal Complexes with Pharmacologically Active Nicotinamide and Alanine by pH Metric Technique

Abstract

The main objective of this research work is to carry out the stability constant study of ternary complexes of transition elements with nicotinamide and alanine. Formation of ternary complexes of transition elements like Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) of pharmacologically active Nicotinamide with Alanine was studied by the pH-metric technique at 25±0.1°C in 70%(v/v) ethanol water medium at 0.1M (NaClO4) ionic strength. The stability constants of the Nicotinamide and Alanine were calculated from the half integral method of potentiometric pH titrations data of solutions according to Irving and Rossetti’s method. The stability constants of these ternary complexes were evaluated and Order of stability constant found as Co (II) > Fe (II) > Cu (II) > Ni (II) > Zn (II).